ALI, MEZHER HUSSEIN,BROOKINGS, DANIEL CHRISTOPHER,BROWN, JULIEN ALISTAIR,HUTCHINGS, MARTIN CLIVE,JACKSON, VICTORIA ELIZABETH,KROEPLIEN, BORIS,PORTER, JOHN ROBERT,QUINCEY, JOANNA RACHEL
申请号:
CA2931026
公开号:
CA2931026A1
申请日:
2014.12.08
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
A series of substituted imidazo[1,2-b]pyridazine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.