Julian Paul Henschke,Xiaoheng Zhang,Chu Guodong,Lijun Mei,Yung Fa Chen
申请号:
US13429827
公开号:
US08338586B2
申请日:
2012.03.26
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A method of making cladribine with an increased purity comprising:a) dissolving crude cladribine in a protic solvent in the presence of a base to form a solution comprising dissolved crude cladribineb) maintaining the solution at an elevated temperature so that the solution is homogeneous until the amount of protected or partially protected nucleoside impurities in the solution is reduced to a pre-determined upper limit andc) cooling the solution of step b) so that crystals of cladribine are formed and isolated.