PEREZ ARIANNE,SABATINO MARIANNA,ROSENBERG STEVEN A,RESTIFO NICHOLAS P
申请号：
IN201817018192
公开号：
IN201817018192A
申请日:
2018.05.15
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
Provided herein are methods for delaying or inhibiting T cell maturation or differentiation in vitro for a T cell therapy comprising contacting one or more T cells from a subject in need of a T cell therapy with an AKT inhibitor and at least one of exogenous Interleukin-7 (IL-7) and exogenous Interleukin-15 (IL-15) wherein the resulting T cells exhibit delayed maturation or differentiation. In some embodiments the method further comprises administering the one or more T cells to a subject in need of a T cell therapy.
