KITE PHARMA, INC.;The United States of America, As Represented By The Secretary, Department Of Health And Human Services;The United States of America, As Represented By The Secretary, Department Of He
发明人:
PEREZ, Arianne,SABATINO, Marianna,ROSENBERG, Steven A.,RESTIFO, Nicholas P.,ROSENBERG, Steven A.,S‧A‧羅森伯格,RESTIFO, Nicholas P.,N‧P‧萊斯蒂夫
申请号：
HK18114455
公开号：
HK1255319A1
申请日:
2018.11.13
申请国别(地区):
HK
年份:
2019
代理人:
摘要：
Provided herein are methods for delaying or inhibiting T cell maturation or differentiation in vitro for a T cell therapy, comprising contacting one or more T cells from a subject in need of a T cell therapy with an AKT inhibitor and at least one of exogenous Interleukin-7 (IL-7) and exogenous Interleukin-15 (IL-15), wherein the resulting T cells exhibit delayed maturation or differentiation. In some embodiments, the method further comprises administering the one or more T cells to a subject in need of a T cell therapy.
