Kite Pharma; Inc.;The United States of America, as represented by the Secretary Department of Health and Human Services;Kite Pharma, Inc.
发明人:
Perez, Arianne,Sabatino, Marianna,Rosenberg, Steven A.,Restifo, Nicholas P.
申请号：
AU2016341966
公开号：
AU2016341966A1
申请日:
2016.10.20
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Provided herein are methods for delaying or inhibiting T cell maturation or differentiation in vitro for a T cell therapy, comprising contacting one or more T cells from a subject in need of a T cell therapy with an AKT inhibitor and at least one of exogenous Interleukin-7 (IL-7) and exogenous Interleukin-15 (IL-15), wherein the resulting T cells exhibit delayed maturation or differentiation. In some embodiments, the method further comprises administering the one or more T cells to a subject in need of a T cell therapy.
