MACKAY MEDICAL FOUNDATION THE PRESBYTERIAN CHURCH IN TAIWAN MACKAY MEMORIAL HOSPITAL
发明人:
LU, YEN-TA,CHANG, CHIA-MING,WEI, TSAI-YIN
申请号：
CA2988641
公开号：
CA2988641A1
申请日:
2016.06.12
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The disclosure found that TLT-1 directly binds to immune cells and triggers cells to express immunosuppressive phenotypes； i.e., down-regulation of HLA-DR and up-regulation of PD-L1. The induction of PD-L1 and reduction of HLA-DR by TLT-1 or TLT-1-derived polypeptides can therefore be useful in treating diseases associated with immune hyper-reactivity, such as autoimmune diseases, hypersensitivity reactions, transplantation rejections and graft versus host disorders.
