Mackay Medical Foundation the Presbyterian Church in Taiwan Mackay Memorial Hospital
发明人:
Lu, Yen-Ta,Chang, Chia-Ming,Wei, Tsai-Yin
申请号：
AU2016274175
公开号：
AU2016274175A1
申请日:
2016.06.12
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The disclosure found that TLT-1 directly binds to immune cells and triggers cells to express immunosuppressive phenotypes； i.e., down-regulation of HLA-DR and up-regulation of PD-L1. The induction of PD-L1 and reduction of HLA-DR by TLT-1 or TLT-1-derived polypeptides can therefore be useful in treating diseases associated with immune hyper-reactivity, such as autoimmune diseases, hypersensitivity reactions, transplantation rejections and graft versus host disorders.
