THE USA; DEPT. OF HEALTH AND HUMAN SERVICES; AS REPRESENTED BY THE SECRETARY
发明人:
BOYINGTON, JEFFREY C.,GRAHAM, BARNEY S.,MASCOLA, JOHN R.,YASSINE, HADI M.,CORBETT, KIZZMEKIA S.,MOIN, SYED M.,WANG, LINGSHU,KANEKIYO, MASARU
申请号：
CA3035443
公开号：
CA3035443A1
申请日:
2017.09.01
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
