您的位置: 首页 > 农业专利 > 详情页

GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTOR
专利权人:
AMGEN INC.
发明人:
FOX, GARY, M.,WEN, DUANZHI,JING, SHUQIAN
申请号:
EA19980000933
公开号:
EA002924(B1)
申请日:
1997.04.15
申请国别(地区):
欧亚专利组织
年份:
2002
代理人:
摘要:
1. An isolated and purified neurotrophic factor receptor human protein, obtained from glial cell line-derived neurotrophic factor (GDNFR) comprising an amino acid sequence as depicted in Figure 2 SEQ ID No: 2 and analogs thereof, obtained by exclusion, addition and/or substitution of amino acids in said sequence with preservation by the finite molecule of GDNFR activity, wherein the protein is capable of complexing with glial cell line-derived neurotrophic factor (GDNF) and thereby mediating cell response to GDNF. 2. A protein of Claim 1 comprising the amino acid sequence from Ser<18> to Pro<446>, as depicted in Figure 2 (SEQ ID No: 2). 3. A protein of Claim 1 comprising the amino acid sequence from Asp<25> to Leu<447>, as depicted in Figure 2 (SEQ ID No: 2). 4. A protein of Claim 1 comprising the amino acid sequence from Cys<29> to Cys<442>, as depicted in Figure 2 (SEQ ID No: 2). 5. An isolated and purified neurotrophic factor receptor rat protein, obtained from glial cel
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充