Helena Ågerstam,Thoas Fioretos,Marcus Järås,Cecilia Ann-Christin Malmborg Hager,Kjell Sjöström,Agneta Svedberg,Karin von Wachenfeldt
申请号：
US16358459
公开号：
US10752692B2
申请日:
2019.03.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides an antibody or an antigen-binding fragment thereof with binding specificity for human interleukin-1 receptor accessory protein (IL1RAP) wherein the antibody or antigen-binding fragment is capable of inhibiting the binding of antibody ‘；CAN04’； to human IL1RAP. The invention further provides the use of such antibodies or an antigen-binding fragments in the treatment and/or diagnosis of IL-1 associated diseases and conditions, including cancers such as acute myeloid leukemia and melanoma.
