Helena Ågerstam,Thoas Fioretos,Marcus Järås,Cecilia Ann-Christin Malmborg Hager,Kjell Sjöström,Agneta Svedberg,Karin von Wachenfeldt
申请号：
US15255585
公开号：
US09796783B2
申请日:
2016.09.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present disclosure provides an antibody or an antigen-binding fragment thereof with binding specificity for human interleukin-1 receptor accessory protein (IL1 RAP) wherein the antibody or antigen-binding fragment is capable of inhibiting the binding of antibody ‘CAN04’ to human IL1 RAP. The disclosure further provides the use of such antibodies or an antigen-binding fragments in the treatment and/or diagnosis of IL-1 associated diseases and conditions, including cancers such as acute myeloid leukemia and melanoma.
