ANTI HUMAN INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN (IL1 RAP) ANTIBODIES AND USES THEREOF

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专利权人:

CANTARGIA AB

发明人:

ÅGERSTAM, HELENA,FIORETOS, THOAS,JÄRÅS, MARCUS,MALMBORG HAGER, CECILIA ANN-CHRISTIN,SJÖSTRÖM, KJELL,SVEDBERG, AGNETA,VON WACHENFELDT, KARIN

申请号：

SG11201607322P

公开号：

SG11201607322PA

申请日:

2015.03.05

申请国别(地区):

SG

年份:

2016

代理人:

摘要：

The present disclosure provides an antibody or an antigen-binding fragment thereof with binding specificity for human interleukin-1 receptor accessory protein (IL1 RAP) wherein the antibody or antigen-binding fragment is capable of inhibiting the binding of antibody 'CAN04' to human IL1RAP. The disclosure further provides the use of such antibodies or an antigen-binding fragments in the treatment and/or diagnosis of IL-1 associated diseases and conditions, including cancers such as acute myeloid leukemia and melanoma.

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