KALLA, RAO,PERRY, THAO,ELZEIN, ELFATIH,VARKHEDKAR, VAIBHAV,LI, XIAOFEN,IBRAHIM, PRABHA,PALLE, VENKATA,XIAO, DENGMING,ZABLOCKI, JEFF
申请号：
CA2524778
公开号：
CA2524778C
申请日:
2003.05.06
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Disclosed are compounds that are A2B adenosine receptorantagonists, useful for treating various disease states, including asthma anddiarrhea.In general, disclosed are compounds of Formula I or Formula II:(see formula Formula I) (see formula Formula II)wherein:R1 and R2 are independently chosen from hydrogen, optionallysubstituted alkyl, or a group -D-E, in which D is a covalent bond or alkylene,andE is alkoxy, cycloalkyl, aryl, heteroaryl, heterocyclyl, alkenyl, or alkynyl,each ofwhich is optionally substituted；R3 is hydrogen, optionally substituted alkyl or optionally substitutedcycloalkyl；X is optionally substituted arylene or heteroarylene；Y is a covalent bond or optionally substituted alkylene in which onecarbon atom can be optionally replaced by -O-, -S-, or -NH-；Z is hydrogen, optionally substituted monocyclic aryl or optionallysubstituted monocyclic heteroaryl.
