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Therapeutically Active compounds and Methods of use
- 专利权人:
- AGIOS PHARMACEUTICALS; INC.
- 发明人:
- BYRON DLBARRE,JEREMY TRAVINS,LI ZHANG,SHUNQI YAN,TAO GUO,GIOVANNI CIANCHETTA,JEFFREY O. SAUNDERS,JANETA POPOVICI-MULLER,FRANCESCO G. SALITURO
- 申请号：
- ARP130100062
- 公开号：
- AR090411A1
- 申请日:
- 2013.01.07
- 申请国别(地区):
- AR
- 年份:
- 2014
- 代理人:
- 摘要：
- Useful compounds for treating cancer and methods of treating cancer are provided which comprises administering to a subject in need a compound described herein. Claim 1: A compound having formula (1) or a pharmaceutically acceptable salt or hydrate thereof, wherein: ring A is an optionally substituted 5-6 membered monocyclic aryl or monocyclic heteroaryl； ring B is an optionally substituted 5-6 membered monocyclic aryl or monocyclic heteroaryl； R¹ and R³ are each independently selected from hydrogen, C₁₋₄-alkyl,haloalkyl C₁₋₄,-O-ordio c833318324y and CN, wherein part of R1 is replaced by - Oh, nh832222；3. NH (lessor c8332121) or n (lessor c832131) c83222；R² is selected from: - (C₁₋₆ alkyl),- (alquenilo o alquinilo C)- (alquileno C) -N (R) - (alquileno C) -O- (alquilo C)- (alquileno C) -N (R) - (alquileno C) -Q - (alquileno C) -N (R) (R)- (alquileno C) -N (R) -S (O) - (alquilo C)- (C₁₋₆ alkylene) -N (R⁶) -S (O) ₁₋₂- (C₀₋₆ alkyl) -Q, - (C₁₋₆ alkylene) -S (O) ₁₋₂-N (R⁶) (R⁶),- (C₁₋₄ alkylene) -S (O) ₁₋₂-N (R⁶) - (C₁₋₆ alkylene) -Q, -C (O) N (R⁶) - (C₁₋₆ alkylene) -C (O ) - (C₀₋₆ alkylene) -O- (C₁₋₆ alkyl),-C (O) N (R⁶) - (C₁₋₆ alkylene) -C (O) - (C₀₋₆ alkylene) -O- (C₀₋₆ alkylene) -Q, - (C₁₋₆ alkylene) -OC ( O) - (C₁₋₆ alkyl),- (alquileno C) -O-C (O) - (alquilo C) -Q - (alquileno C) -O- (alquilo C)- (C₁₋₆ alkylene) -O- (C₁₋₆ alkylene) -Q, - (C₀₋₆ alkylene) -C (O) - (C₀₋₆ alkylene) -O- (C₁₋₆ alkyl),- (alquileno C) -C (O) - (alquileno C) -O- (alquileno C) -Q - (alquileno C) -O-C (O) - (alquilo C)- (C₁₋₆ alkylene) -O-C (O) - (C₀₋₆ alkylene) -Q, - (C₀₋₆ alkylene) -C (O) N (R⁶) - (C₁₋₆ alkyl),- (alquileno C) -C (O) N (R) - (alquileno C) -Q - (alquileno C) -N (R) C (O) - (alquilo C)- (C₁₋₆ alkylene) -N (R⁶) C (O) - (C₀₋₆ alkylene) -Q, - (C₀₋₆ alkylene) -S (O) ₀₋₂- (C₁₋₆ alkyl),- (C₀₋₆ alkylene) -S (O) ₀₋₂- (C₀₋₆ alkylene) -Q, - (C₁₋₆ alkylene) -N (R⁶) -C (O) -N (R⁶) - (alkyl C₁₋₆),- (C₀₋₆ alkylene) -Q, - (C₀₋₆ alkylene) -C (O) - (C₁₋₆ alkyl),- (C₀₋₆ alkylene) -C (O) - (C₀₋₆
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
