Urszula Grabowska;Magnus Nilsson;Lourdes Salvador Oden;Pia Kahnberg
发明人:
Magnus Nilsson,Lourdes Salvador Oden,Pia Kahnberg,Urszula Grabowska
申请号：
US12986830
公开号：
US08198283B2
申请日:
2011.01.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds of the formula II:whereinR2 is the side chain of leucine, isoleucine, cyclohexylglycine, O-methyl threonine, 4-fluoroleucine or 3-methoxyvaline；R3 is H, methyl or F；Rq is trifluoromethyl and Rq′ is H or Rq and Rq′ define keto；Q is a p-(C1-C6alkylsulphonyl)phenyl- or an optionally substituted 4-(C1-C6alkyl)piperazin-1-yl-thiazol-4-yl-moiety have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases.
