INHIBITEURS DE LA SUMOYLATION DE CRMP2 ET UTILISATIONS ASSOCIEES

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专利权人:

ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人:

KHANNA, MAY,KHANNA, RAJESH,GOKHALE, VIJAY,CHAWLA, REENA

申请号：

CA3090492

公开号：

CA3090492A1

申请日:

2016.10.07

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention provides compounds that can modulate the amount of Nav 1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav 1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav 1.7 protein on the cellular surface and/or SUMOylation of CRMP2.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/