ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人:
May Khanna,Rajesh Khanna,Vijay Gokhale,Reena Chawla
申请号：
US16596508
公开号：
US20200093822A1
申请日:
2019.10.08
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides compounds that can modulate the amount of Nav1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav1.7 protein on the cellular surface and/or SUMOylation of CRMP2.
