CRMP2 SUMOylation inhibitors and uses thereof

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专利权人:

Arizona Board of Regents on behalf of The University of Arizona

发明人:

KHANNA, May,KHANNA, Rajesh,GOKHALE, Vijay,CHAWLA, Reena

申请号：

AU2020200720

公开号：

AU2020200720A1

申请日:

2020.01.31

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

#$%^&*AU2020200720A120200220.pdf#####CRMP2 SUMOylation Inhibitors and Uses Thereof Abstract The present invention provides compounds that can modulate the amount of Navl.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Navl.7 protein on the cellular surface and/or SUMOylation of CRMP2. AH26(24267596 1):RTK

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/