GlaxoSmithKline Intellectual Property Development Limited
发明人:
David Norman DEATON,Yu GUO,Ashley Paul HANCOCK,Christie SCHULTE,Barry George SHEARER,Emilie Despagnet SMITH,Eugene L. STEWART,Stephen Andrew THOMSON
申请号：
US16341113
公开号：
US20190241554A1
申请日:
2017.10.12
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A compound of formula (I)wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein.The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
