GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
DEATON, DAVID NORMAN,GUO, YU,HANCOCK, ASHLEY PAUL,SCHULTE, CHRISTIE,SHEARER, BARRY GEORGE,SMITH, EMILIE DESPAGNET,STEWART, EUGENE L.,THOMSON, STEPHEN ANDREW
申请号：
CA3038756
公开号：
CA3038756A1
申请日:
2017.10.12
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A compound of formula (I), wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
