GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
DEATON, David Norman,GUO, Yu,HANCOCK, Ashley Paul,SCHULTE, Christie,SHEARER, Barry George,SMITH, Emilie Despagnet,STEWART, Eugene L.,THOMSON, Stephen Andrew
申请号：
PH12019500811
公开号：
PH12019500811A1
申请日:
2019.04.12
申请国别(地区):
PH
年份:
2020
代理人:
摘要：
A compound of formula (I), wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
