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Bivalent diazo bicyclic SMAC mimetics and their uses
专利权人:
The Regents of the University of Michigan
发明人:
WANG, Shaomeng,SUN, Haiying
申请号:
ES10825596
公开号:
ES2643233T3
申请日:
2010.10.20
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound having Formula I: ** (See formula) ** where R and R 'are independently selected from the group consisting of hydrogen and saturated straight or straight chain C1 to C6 alkyl optionally substituted with one, two, three or more substituents independently selected from hydroxy, nitro, cyano, halo, amino, cycloalkyl, aryl, heteroaryl, heterocycle, alkoxy, aryloxy, aralkyloxy, alkylthio, carboxamido or sulfonamido; R1 and R1 'are independently alkylamino; T and T 'are independently heteroaryl optionally substituted with one to four substituents, which are independently selected from halo, nitro, cyano, hydroxy, amino, alkyl, haloalkyl, hydroxyalkyl, aralkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, alkoxy, aryloxy, aralkyloxy, alkylthio, carboxamido or sulfonamido; U and U 'are independently selected from the group consisting of CH and N; m and m 'are independently 0-3; n and n 'are independently 1-3; p and p 'are independently 1-2; and L is a linker where L is selected from the group consisting of A) - (CH2) q- or -CO- (CH2) r-CO-; where: q is 2-50; r is 1-50; and one or more groups -CH2- can be optionally and independently replaced with -CR5aR5b-, -CH>; = CH-, -C≡C-, -O-, -S-, -N (R6) -, C>; = O , S>; = O, heterocycle, aryl or heteroaryl; where: R5a is selected from the group consisting of alkyl, aralkyl, cycloalkyl, aryl, heteroaryl, heterocycle, halo, nitro, cyano, hydroxy, amino, alkoxy, aryloxy, arylalkyl, alkylthio, carboxamido and sulfonamido; R5b is selected from the group consisting of hydrogen, alkyl, aralkyl, cycloalkyl, aryl, heteroaryl, heterocycle, halo, nitro, cyano, hydroxy, amino, alkoxy, aryloxy, arylalkyl, alkylthio, carboxamido and sulfonamido; or R5a and R5b taken together with the carbon to which they are attached form a 3- to 8-membered cycloalkyl or heterocycle; and R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl and heteroaryl; and B) -CO- (CH2) v-O- (CH2) w-CO-, where v and w ar
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