A system for usage guidance using wireless communication includes a portable computing device, wherein the portable computing device is designed and configured to wirelessly receive a signal from a wireless signal generator located at an item, parse the first signal for at least a textual element, extract a signal generator class identifier from at least a textual element, identify a remote data structure as a function of the signal generator identifier, retrieve, from the remote data structure, at least an identifier-specific datum, and generate identifier-specific usage guidance as a function of the at least an identifier-specific datum. The system includes a user output component coupled to the portable computing device, wherein the user output component is configured to provide the identifier-specific usage guidance to the user.