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ANTIBODY-DRUG CONJUGATES AND IMMUNOTOXINS
专利权人:
S.L.;ONCOMATRYX BIOPHARMA
发明人:
KONTERMANN, ROLAND,PFIZENMAIER, KLAUS,FERRER, CRISTINA,FABRE, MYRIAM,SIMON, LAUREANO
申请号:
CA2937455
公开号:
CA2937455A1
申请日:
2015.02.04
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula (I): A-(L-D)p or a pharmaceutically acceptable salts or solvates thereof, wherein A is an antibody that selectively binds FAP; L is a linker; D is a drug comprising a cytolysin or a Nigrin-b A-chain; and p is 1 to 10, and to use of such conjugates in the therapeutic treatment of tumors. Methods of producing such conjugates and components for use in such methods are disclosed.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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