ANTIBODY-DRUG CONJUGATES AND IMMUNOTOXINS

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专利权人:

发明人:

申请号：

EP15705778.7

公开号：

EP3102244A2

申请日:

2015.02.04

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula I: A-(L-D)p (I) or a pharmaceutically acceptable salts or solvates thereof, wherein: A is an antibody that selectively binds FAP L is a linker D is a drug comprising a cytolysin or a Nigrin-b A-chain and p is 1 to 10, and to use of such conjugates in the therapeutic treatment of tumors. Methods of producing such conjugates and components for use in such methods are disclosed.

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