Roland Kontermann,Klaus Pfizenmaier,Cristina Ferrer,Myriam Fabre,Laureano Simon
申请号：
US15116430
公开号：
US20170007716A1
申请日:
2015.02.04
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula I: A-(L-D)p (I) or a pharmaceutically acceptable salts or solvates thereof, wherein: A is an antibody that selectively binds FAP L is a linker D is a drug comprising a cytolysin or a Nigrin-b A-chain and p is 1 to 10, and to use of such conjugates in the therapeutic treatment of tumors. Methods of producing such conjugates and components for use in such methods are disclosed.
