A method for treating a liver disease is disclosed. The method includes steps of providing a subject in need thereof; and administering one selected from the group consisting of Piperazinyl Analogs and Piperazinyl Complex Analogs compound, pharmaceutically acceptable salts thereof; and a pharmaceutical composition thereof to the subject in a dosage.本發明揭示肝臟疾病之治療方法。該方法步驟包括:提供一肝臟疾患動物;投予足供療效用量之藥物組合物於該動物,其製劑係選自哌嗪基類似物、哌嗪基複合類似物之一所組成之藥物組合物。