STEINKUHLER, M. CHRISTIAN,GALLINARI, M. PAOLA,OSSWALD, BIANCA,SEWALD, NORBERT,RITZEFELD, MARKUS,FRESE, MARCEL,FIGUERAS, EDUARD,PETHO, LILLA
申请号：
CA2979585
公开号：
CA2979585A1
申请日:
2016.03.15
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to antibody- or peptide-drug conjugate compounds where one or more cryptophycin derivatives (macrocyclic depsipeptide) are covalently attached by a self-immolative linker which binds to one or more tumor-associated antigens or cell-surface receptors. The linker contains a cleavage site for proteases and a dipeptide unit able to form a diketopiperazine. These compounds may be useful in methods of diagnosis or treatment of cancer, and other diseases and disorders, such as immune or infective diseases.
