The present invention relates to a self-microemulsifying system, preferably comprising active pharmaceutical ingredient, and a medicine prepared therefrom. This invention also relates to a process for preparing a solid self-microemulsifying system. In addition, it relates to a use of the self-microemulsifying system and a use of microcrystalline cellulose in admixture with the self-microemulsifying system. Specifically it describes a process for preparing a self-microemulsifying system comprising dispersing microcrystalline cellulose in a solvent, wherein the solvent further contains a viscosity enhancer, mixing the solvent with a self-microemulsifying system and spray drying the obtained mixture. In addition It provides the process comprising mixing a solid support and self-microemulsifying system to form a primary mixture and further granulating said primary mixture with a solution or suspension of a granulation binder. Both processes remarkably enhance processability of the solid self-microemulsifying system. Product and medicine obtainable by said processes are also provided.
