Provided herein are compositions comprising acidic extracts of Commiphora molmol (Myrrh) resin for the treatment and prevention of oral mucositis, mucosal infections, topical inflammations, bed sores, decubitis, inflammations of the gastrointestinal tract, canker sores, dental mouth lining ulcers, Behcet disease, and for acute and chronic wound healing. Also provided are methods for producing the disclosed compositions.