TOKUSHIMA UNIVERSITY;MEIJI PHARMACEUTICAL UNIVERSITY
发明人:
Koji ITO,Hitoshi SAKURABA,Daisuke TSUJI
申请号：
US14436833
公开号：
US20160137994A1
申请日:
2013.10.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided is a modified β-subunit of human β-hexosaminidase which has the activity derived from the α-subunit of wild-type human β-hexosaminidase and has the resistance to protease. A protein comprising an amino acid sequence having substitutions of the 312th to the 318th amino acids with glycine, serine, glutamic acid, proline, serine, glycine and threonine in order, respectively, in an amino acid sequence of a β-subunit of wild-type human β-hexosaminidase.
