The present invention relates in general to the field of organic chemistry and in particular to the preparation of N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl )-N- methylmethanesulfonamide (I), N-(4-(4-fluorophenyl)-5-(bromomethyl)-6-isopropylpyrimid in-2- yl)-N-methylmethanesulfonamide (II) and N-(4-(4-fluorophenyl)-5-(hydroxymethyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (III), key intermediates in preparation of Rosuvastatin.La presente invención se refiere en general al campo de la química orgánica, y en particular a la preparación de la N-(4-(4-fluoro-fenil)-6-isopropil-5-metil-pirimidin-2-il)-N-metil -metan-sulfonamida (I), de la N-(4-(4-fluoro-fenil)-5-(bromo-metil )-6-iso-propil-pirimidin-2-il)-N-metil-metan-sulfonamida (II), y de la N-(4-(4-fIuoro-fenil)-5-(hidroxi-metil)-6-isopropil-pirimidi n-2-il)-N-metil-metan-sulfonamida (III), como los intermediarios clave en la preparación de la rosuvastatina.