Otto Phanstiel, IV;Otto Phanstiel;Jennifer J. Archer; IV
发明人:
Otto Phanstiel, IV,Jennifer J. Archer
申请号：
US14962195
公开号：
US09730902B2
申请日:
2015.12.08
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Novel polyamine transport inhibitors have been synthesized and demonstrated to block the uptake of native polyamines into human cancer cells. A combination therapy of the transport inhibitor and DFMO (a drug which blocks polyamine biosynthesis) provided synergistic activity against a metastatic human colon cancer cell line. The strategy uses polyamine depletion and polyamine metabolism to generate reactive oxygen species within cells as a novel way to treat cancers. This approach may be implemented for widespread use in the treatment of diseases which rely upon polyamine transport activity for proliferation.
