UNIVERSITÀ DEGLI STUDI DI SASSARI;The Regents of the University of Michigan
发明人:
Nouri NEAMATI,Mario SECHI
申请号：
US16083376
公开号：
US20190308942A1
申请日:
2017.03.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazolinedione structure which function as reactive oxygen species (ROS) inducers and inhibitors of mitochondrial activity within cancer cells (e.g., pancreatic cancer cells), and their use as therapeutics for the treatment of cancer (e.g., pancreatic cancer) and other diseases.
