A topical composition useful for ameliorating the effects of aging comprising: Narcissus tazetta extract and at least one salicylate selected from the group consisting of salicin, salicyl hydroxamate, and combinations thereof wherein the Narcissus tazetta extract and the at least one salicylate are provided in an amount sufficient to inhibit age-related isoform of NADH oxidase (arNOX). Preferably the salicylate is derived from a plant source selected from willow, maize, crepis, poplar, viburnam, Aspergillus, alangium, birch, bupleurum, colchicum, spurge, filipendulum, gardenia, lithospermum, tobacco, mistletoe, or combinations thereof.
