A SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR MUTANT

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专利权人:

发明人:

申请号：

EP09753407.7

公开号：

EP2221314B1

申请日:

2009.01.12

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

A soluble tumor necrosis factor receptor 2 (TNFRII) mutant has an amino acid substitution at position 92Glu compared with the wild TNFRII. The mutant improves the cytotoxicity capacity of neutralizing TNFalpha and lymphotoxin. The mutant and fusion protein comprising it are useful for the treatment of TNFalpha and lymphotoxin related diseases.

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