CLAY, Julia Marie,EDGE, Albert,HIPSKIND, Philip Arthur,GILL, John C.,PATEL, Bharvin Kumar,VAN ES, Helmuth Hendrikus Gerardus,WROBLESKI, Aaron D.,ZHAO, Gaiying
申请号：
PE2018000012
公开号：
PE20180412A1
申请日:
2016.07.01
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
It refers to 4,4,4-trifluoro-n - ((2S) - 1 - (9-methoxy-3,3-dimethyl-5-oxo-2,3,5,6-tetrahydro-1h-benzzo [F] pirrolo [1,2-a] azepin-6-il) amine) - 1-oxopropan-2-il) butylamine (formula 1)；Y N - ((2S) - 1 - ((8,8-dimethyl-6-oxo-6,8,9,10-tetrahydro-5h-pyridine [3,2-f] pyridine [1,2-a] azerbaijani-5-il) amine) - 1-oxopropan-2-il) - 4,4-trifluoromethane (formula 2)；Or an acceptable salt He also mentioned a pharmaceutical composer These compounds inhibit the unsterilized via Notch and are effective tools for cancer treatment.SE REFIERE A LOS COMPUESTOS: 4,4,4-TRIFLUORO-N-((2S)-1-((9-METOXI-3,3-DIMETIL-5-OXO-2,3,5,6-TETRAHIDRO-1H-BENZO[f]PIRROLO[1,2-a]AZEPIN-6-IL)AMINO)-1-OXOPROPAN-2-IL)BUTANAMIDA (FORMULA 1)； Y N-((2S)-1-((8,8-DIMETIL-6-OXO-6,8,9,10-TETRAHIDRO-5H-PIRIDO[3,2-f]PIRROLO[1,2-a]AZEPIN-5-IL)AMINO)-1-OXOPROPAN-2-IL)-4,4,4-TRIFLUOROBUTANAMIDA (FORMULA 2)； O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA SENALIZACION DE LA VIA NOTCH SIENDO UTILES PARA EL TRATAMIENTO DE CANCER
