CLAY, Julia Marie,EDGE, Albert,HIPSKIND, Philip Arthur,GILL, John C.,PATEL, Bharvin Kumar,VAN ES, Helmuth Hendrikus Gerardus,WROBLESKI, Aaron D.,ZHAO, Gaiying
申请号：
PE0000122018
公开号：
PE4122018A1
申请日:
2016.07.01
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Refers to compounds: 4,4,4 - trifluoro - N - ((2S) - 1 - ((1 - methoxy - 3,3 - dimethyl - 5 - oxo 2,3,5,6 - tetrahydro - 1H benzo [f] pirrolo [12 -] azepin - 6 - il) amino) - 2 - 1 - oxopropan - il) butanamide (Formula 1) and N - ((2S) - 1 - ((8.8 - dimethyl - 6 - oxo 6,8,9,10 - tetrahydro - 5H - pirido [3,2 - F pirrolo [1,2-a] azepin] - 5 - IL) amino) - 2 - 1 - oxopropan) - 4,4, - il4 - trifluorobutanamida (Formula 2) or a pharmaceutically acceptable Salt thereof. It also relates to a Pharmaceutical composition.These compounds are inhibitors of the Notch Signalling Pathway to be useful for the treatment of cancerSE REFIERE A LOS COMPUESTOS: 4,4,4-TRIFLUORO-N-((2S)-1-((9-METOXI-3,3-DIMETIL-5-OXO-2,3,5,6-TETRAHIDRO-1H-BENZO[f]PIRROLO[1,2-a]AZEPIN-6-IL)AMINO)-1-OXOPROPAN-2-IL)BUTANAMIDA (FORMULA 1) Y N-((2S)-1-((8,8-DIMETIL-6-OXO-6,8,9,10-TETRAHIDRO-5H-PIRIDO[3,2-f]PIRROLO[1,2-a]AZEPIN-5-IL)AMINO)-1-OXOPROPAN-2-IL)-4,4,4-TRIFLUOROBUTANAMIDA (FORMULA 2) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA SENALIZACION DE LA VIA NOTCH SIENDO UTILES PARA EL TRATAMIENTO DE CANCER
