<;P>;PROBLEM TO BE SOLVED: To provide an endothelin-1 mRNA-expression elevation inhibitor, an SCF mRNA-expression elevation inhibitor, a bFGF mRNA-expression elevation inhibitor and a POMC mRNA-expression elevation inhibitor, each comprising a flavone compound having inhibitory actions against elevations of endothelin-1 mRNA expression, SCF mRNA expression, bFGF mRNA expression and POMC mRNA expression as an active ingredient. <;P>;SOLUTION: The endothelin-1 mRNA-expression elevation inhibitor, the SCF mRNA-expression elevation inhibitor, the bFGF mRNA-expression elevation inhibitor and the POMC mRNA-expression elevation inhibitor each comprises a carambolaflavone compound as the active ingredient. <;P>;COPYRIGHT: (C)2011,JPO&INPIT