LEE, MI OCK,이미옥,LEE, BONG JIN,이봉진,KIM, EUN JIN,김은진,KIM, HYUN HWI,김현휘
申请号：
KR1020110074144
公开号：
KR1020130014700A
申请日:
2011.07.26
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A pharmaceutical composition containing a novel peptide which enhances transcription activity of VEGF(Vascular Endothelial Growth Factor) is provided to activate VEGF gene through HIF-1alpha activation and to promote wound healing, skin tissue regeneration, and hair growth. CONSTITUTION: A pharmaceutical composition for wound healing and skin tissue regeneration contains a peptide with a base sequence selected from sequence numbers 1-3. The peptide enhances the expression of HIF-1alpha, VEGF, fibronectin, or collagen. The peptide proliferates VEGF and enhances cell migration. A method for wound healing or skin tissue regeneration comprises a step of administering the pharmaceutical composition to an individual. [Reference numerals] (AA) Gauze； (BB) Existing salve； (CC) Base； (DD) **p<；0.01 and ***p<；0.001 as compared with base control(base)본 발명은 HIF-1α 유전자를 활성화시켜 상처치료에 중요한 혈관내피세포성장인자(VEGF)의 전사 활성을 증가시키는 신규한 펩타이드 및 이를 포함하는 약학적 조성물 등을 제공한다. 상기 본 발명의 약학적 조성물은 상처치료, 피부 조직 재생과 발모 촉진 등의 효과를 가진다.
