DS Pharma Animal Health Co. Ltd.;AnGes MG, Inc.;Osaka University
发明人:
申请号：
EP15861370.3
公开号：
EP3222289A1
申请日:
2015.11.20
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention provides a combination preparation for inducing a specific immune response to an antigenic peptide, which contains(I) the antigenic peptide, and(II) an expression vector encoding a chimeric hepatitis B virus core antigen polypeptide, into which the antigenic peptide has been inserted or added, wherein said antigenic peptide is inserted in a region of amino acid residues 74 - 87 or 130 - 138 of the hepatitis B virus core antigen polypeptide, or added to the N-terminal or C-terminal of the hepatitis B virus core antigen polypeptide, whereinthe antigenic peptide of (I) and the expression vector of (II) are substantially simultaneously administered to a subject.
