Thomas M. SCHMITT,Philip D. GREENBERG,Aude G. CHAPUIS,Harlan S. ROBINS,Anna M. SHERWOOD
申请号：
US16064161
公开号：
US20180369280A1
申请日:
2016.12.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure provides TCRs with high or enhanced affinity against various tumor associated antigens (including human Wilms tumor protein 1 (WT 1) epitopes and mesothelin epitopes), T cells expressing such high affinity antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating diseases or disorders in which cells overexpress one or more of these antigens, such as in cancer.
