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T-cell receptor-deficient T cell compositions
专利权人:
THE TRUSTEES OF DARTMOUTH COLLEGE
发明人:
Charles L. Sentman
申请号:
US15815261
公开号:
US10689617B1
申请日:
2017.11.16
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.
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