14-O-{[(2-(optionally substituted-hydroxy)-cyclohexyl)-sulfanyl]-acetyl}-mutilins which are further substituted at the cyclohexyl group by an acylated amino group, salts and solvates thereof, pharmaceutical compositions comprising such compounds and their use as a pharmaceutical, e.g. for the treatment of diseases mediated by microbes and for the treatment of inflammation where microbes are mediating said inflammation.進一步在環己基上經醯基化的胺基取代之14-O-{[(2-(隨意地經取代的-羥基)-環己基)-硫基(sulfanyl)]-乙醯基}-馬替琳(mutilin)、其鹽類和溶劑化物、含此類化合物之醫藥組成物和及作為藥物之用途，例如，用於治療微生物類媒介的疾病和用於治療發炎，其中微生物類媒介該發炎。
