Compounds of formula I, which are 14-O-{[(2-(optionally substituted-hydroxy)-cyclohexyl)-sulfanyl]-acetyl}-mutilins further substituted at the cyclohexyl group by an acylated amino group, salts and solvates thereof, pharmaceutical compositions comprising such compounds and their use as a pharmaceutical, e.g. for the treatment of diseases mediated by microbes and for the treatment of inflammation where microbes are mediating said inflammation.
