14-O-{[(2-(optionally substituted-hydroxy)-cyclohexyl)-sulfanyl]-acetyl}-mutilins which arefurther substituted at the cyclohexyl group by an acylated amino group, saltsand solvatesthereof, pharmaceutical compositions comprising such compounds and their useas apharmaceutical, e.g. for the treatment of diseases mediated by microbes andfor the treatmentof inflammation where microbes are mediating said inflammation. The compoundsofformula I show improved metabolic stability.
