THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY; WALTER REED ARMY INSTITUTE OF RESEARCH
发明人:
VENKATESAN, MALABI M.,RANALLO, RYAN T.,BARNOY, SHOSHANA
申请号：
CA2685132
公开号：
CA2685132C
申请日:
2008.04.25
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Shigella vaccine strains whose primary attenuating feature is deletion of the virG(icsA) gene and additional two or more deletions in setAB(shET1), senA(shET2), senB(shET2- 2), stxAB, and msbB2 genes. Thus, the vaccine strain will have three or more deletions in the identified genes, will be safer, and will reduce or eliminate symptoms of fever and diarrhea in humans. The following specific vaccine strains have been constructed: WRSS3 (.DELTA.senA, .DELTA.senB, .DELTA.virG, .DELTA.msbB2), WRSf2G15 (.DELTA.virG, .DELTA.setAB, .DELTA.senA, .DELTA.senB, .DELTA.msbB2), and WRSd5 (.DELTA.virG, .DELTA. stxAB, .DELTA.senA, .DELTA.senB, .DELTA.msbB2).
