Walter Reed Army Institute of Research;The United States of America as Represented by the Secretary of the Army
发明人:
Barnoy, Shoshana,Venkatesan, Malabi M.,Ranallo, Ryan T.
申请号：
AU2008246150
公开号：
AU2008246150B2
申请日:
2008.04.25
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
Shigella vaccine strains whose primary attenuating feature is deletion of thevirG(icsA) gene and additional two or more deletions in setAB(shET1), senA(shET2),senB(shET2- 2), stxAB, and msbB2 genes. Thus, the vaccine strain will have threeor more deletions in the identified genes, will be safer, and will reduce or eliminatesymptoms of fever and diarrhea in humans. The following specific vaccine strainshave been constructed: WRSS3 (ΔsenA, ΔsenB, ΔvirG, ΔmsbB2),WRSf2G15 (ΔvirG, ΔsetAB, ΔsenA, ΔsenB, ΔmsbB2),and WRSd5 (ΔvirG, Δ stxAB, ΔsenA, ΔsenB, ΔmsbB2).
