This invention relates to glaucoma, and more particularly to use of VE-PTP-null allele to rescue from the glaucoma symptom of elevated intraocular pressure. This invention also relates to conditional knockout of VE-PTP to rescue from the glaucoma symptom of elevated intraocular pressure expressed in an Angiopoietin 1 and Angiopoietin 2 conditional knockout mouse. This invention also relates to the use of VE-PTP-null alleles.