Malabi M. Venkatesan;Shoshana Barnoy;Ryan T. Ranallo
发明人:
Malabi M. Venkatesan,Ryan T. Ranallo,Shoshana Barnoy
申请号：
US12149076
公开号：
US08986708B2
申请日:
2008.04.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Shigella vaccine strains whose primary attenuating feature is deletion of the virG(icsA) gene and additional two or more deletions in setAB(shET1), senA(shET2), senB(shET2-2), stxAB, and msbB2 genes. Thus, the vaccine strain will have three or more deletions in the identified genes, will be safer, and will reduce or eliminate symptoms of fever and diarrhea in humans. The following specific vaccine strains have been constructed: WRSS3 (ΔsenA, ΔsenB, ΔvirG, ΔmsbB2), WRSf2G15 (ΔvirG, ΔsetAB, ΔsenA, ΔsenB, ΔmsbB2), and WRSd5 (ΔvirG, ΔstxAB, ΔsenA, ΔsenB, ΔmsbB2).
